Cheesy Chicken Stuffing Casserole (Simple Weeknight Dinner)

Cheesy Chicken Stuffing Casserole is the ultimate comfort food — creamy, flavorful, and loaded with tender chicken, melty cheese, and savory stuffing. It’s a one-pan dinner that’s easy to prepare and always a hit with the whole family. With its perfectly seasoned layers and golden, crispy topping, this casserole delivers cozy, home-cooked goodness in every bite.

What Is Cheesy Chicken Stuffing Casserole?

Cheesy Chicken Stuffing Casserole is a hearty baked dish made with layers of shredded chicken, creamy sauce, cheese, and stuffing mix. The combination of tender meat, rich sauce, and buttery, crisp stuffing topping makes it a comforting meal perfect for weeknights, potlucks, or holidays. It’s an easy way to turn leftover chicken or rotisserie chicken into a warm, filling dinner.

Reasons to Try Cheesy Chicken Stuffing Casserole

• Quick and Easy – Simple ingredients and minimal prep time.
• Family Favorite – Everyone loves the cheesy, creamy flavor.
• Perfect for Leftovers – A great way to use cooked or rotisserie chicken.
• Comforting and Filling – Layers of creamy sauce and crispy stuffing make it satisfying.
• Freezer-Friendly – Can be made ahead and frozen for later use.
• Versatile – Easy to customize with vegetables or different cheeses.

Ingredients Needed to Make Cheesy Chicken Stuffing Casserole

• 3 cups cooked shredded chicken (rotisserie or boiled)
• 1 box (6 oz) stuffing mix (such as Stove Top)
• 1 can (10 oz) cream of chicken soup
• 1 cup sour cream
• 1 cup shredded cheddar cheese
• ½ cup milk
• 1 cup frozen mixed vegetables (optional)
• 2 tbsp butter (melted)
• ½ tsp salt
• ½ tsp black pepper
• ½ tsp garlic powder
• ½ tsp onion powder

Instructions to Prepare Cheesy Chicken Stuffing Casserole

• Preheat the oven – Set the oven to 375°F (190°C) and lightly grease a 9×13-inch baking dish.
• Prepare the stuffing – In a bowl, combine the stuffing mix with melted butter and hot water as directed on the package. Fluff with a fork and set aside.
• Mix the creamy sauce – In another bowl, stir together cream of chicken soup, sour cream, milk, salt, pepper, garlic powder, and onion powder until smooth.
• Assemble the casserole – Spread shredded chicken evenly across the baking dish. Pour the creamy mixture over the chicken, spreading it evenly.
• Add cheese – Sprinkle half the shredded cheddar cheese over the creamy layer.
• Add vegetables (optional) – Evenly scatter mixed vegetables if using.
• Top with stuffing – Spoon the prepared stuffing over the top, spreading evenly.
• Bake until bubbly – Bake uncovered for 25–30 minutes until the stuffing is golden brown and the casserole is hot throughout.
• Add final cheese layer (optional) – In the last 5 minutes of baking, sprinkle remaining cheese on top and bake until melted.
• Rest and serve – Let cool for 5 minutes before serving for the best texture.

What Goes Well With Cheesy Chicken Stuffing Casserole

• Green Salad – A crisp salad balances the creamy, rich casserole.
• Steamed Broccoli – Adds a healthy and vibrant side.
• Mashed Potatoes – Doubles the comfort and complements the creamy sauce.
• Garlic Bread – Perfect for scooping up the cheesy layers.
• Cranberry Sauce – Adds a sweet-tart contrast to the savory flavor.

Key Tips for Making Cheesy Chicken Stuffing Casserole

• Use pre-cooked chicken – Rotisserie chicken saves time and adds flavor.
• Don’t overbake – Bake just until the top is golden to keep it moist.
• Add sour cream – It enhances creaminess and gives the sauce a smooth texture.
• Mix cheeses – Combine cheddar with mozzarella for extra gooeyness.
• Add vegetables – Frozen peas, carrots, or green beans blend perfectly with the creamy filling.
• Cover if browning too quickly – Loosely cover with foil to prevent burning.
• Let it rest – Resting helps the sauce thicken and makes slicing easier.

Creative Variations of Cheesy Chicken Stuffing Casserole

• Broccoli Chicken Version – Add steamed broccoli florets for a wholesome twist.
• Bacon Lover’s Style – Mix crispy bacon pieces into the chicken layer.
• Spicy Twist – Add a pinch of cayenne or diced jalapeños for a little heat.
• Thanksgiving-Inspired – Add leftover turkey and cranberry sauce for a festive flavor.
• Cheddar Ranch Casserole – Mix a tablespoon of ranch seasoning with the sauce for a zesty taste.
• Low-Carb Option – Skip the stuffing and top with a cauliflower crumble or cheese blend.

Storage Guidelines for Cheesy Chicken Stuffing Casserole

• Refrigeration – Store leftovers in an airtight container for up to 4 days.
• Freezing – Cool completely and wrap tightly in foil or place in a freezer-safe container for up to 2 months.
• Defrosting – Thaw overnight in the refrigerator before reheating.
• Avoid soggy texture – Reheat uncovered to keep the topping crisp.
• Label before freezing – Helps track freshness.

Reheating Tips for Cheesy Chicken Stuffing Casserole

• Oven Method – Reheat covered with foil at 350°F (175°C) for 20–25 minutes until hot.
• Microwave Method – Heat individual servings for 2–3 minutes, stirring halfway through.
• Air Fryer Method – Reheat at 350°F (175°C) for 6–8 minutes for a crispy top.

Nutrition Value (Per Serving)

• Calories: 460 kcal
• Protein: 32 g
• Fat: 24 g
• Carbohydrates: 30 g
• Fiber: 2 g
• Sodium: 850 mg
• Calcium: 210 mg

FAQs

Should I cook the stuffing before adding it to chicken casserole?

Yes, the stuffing should be prepared according to the package instructions before layering it on top of the casserole. This ensures it becomes moist yet crispy when baked and evenly absorbs flavor from the creamy chicken mixture below.

Can I use raw chicken in cheesy chicken stuffing casserole?

It’s best to use pre-cooked chicken for this recipe. Using raw chicken can release excess liquid and make the casserole watery. Rotisserie chicken, grilled, or leftover baked chicken all work perfectly and add rich flavor.

How can I make the casserole creamier?

For an extra creamy texture, add a spoonful of sour cream or cream cheese to the soup mixture. You can also use half-and-half instead of milk for a richer sauce that blends beautifully with the cheese.

Can I prepare cheesy chicken stuffing casserole ahead of time?

Yes, you can assemble the casserole up to a day in advance. Cover it tightly with foil or plastic wrap and refrigerate. When ready to bake, remove from the fridge, let it sit at room temperature for 15 minutes, then bake as directed until hot and bubbly.

Final Words

Cheesy Chicken Stuffing Casserole is a comforting and satisfying dish that brings together all the flavors of a homemade dinner in one pan. With its creamy chicken base, melted cheese, and buttery stuffing topping, it’s the kind of meal that makes everyone feel at home. Perfect for family dinners, gatherings, or weeknight cravings, this casserole is a delicious reminder that simple ingredients can create unforgettable comfort food.

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